Genetics

How Does It Works ?

Genes control everything about a person, from height to eye color. When genes are working normally, the body and its cells function normally. When a misstep occurs in the way a gene works, a genetic disease such as psoriasis may result.

Genes and Psoriasis

You can think of DNA like the instruction book for building a new you. And genes are like the chapters in that book that have specific instructions.So you have some chapters controlling the color of your eyes. And others controlling the color of your hair. And lots of other chapters that control everything else about you. Including your chances for developing Psoriasis.

History of Psoriasis

These genes are actually packaged in units called “chromosomes.” These are like separate books in a collection.Humans have 46 of these chromosomes. Each has many genes “from as few as 70 or 80 on the Y to more than 4000 on chromosome 1.

So far, scientists have found that at least nine different parts of seven separate chromosomes may be controlling Psoriasis. These regions are pretty big and have lots of genes. This makes finding the specific ones involved in Psoriasis very difficult.

However, scientists have managed to find a few. These genes belong to a family called interleukins. Interleukins play an important role in our immune system.

Our immune system helps keep us well by fighting off foreign invaders like bacteria and viruses. An important part of this fight is cells telling each other that there is an invader and where it is. Interleukins are used in this communication.

Scientists have found that these interleukin genes are turned on way too high in the skin of people with PS. This is more evidence that these genes are involved.

But why would interleukins be involved in a skin disease like Psoriasis? Because Psoriasis is an autoimmune disease.

Immunology of Psoriasis

 

Psoriasis is characterised by three main pathophysiological processes namely; 1. Epidermal hyperproliferation and loss of differentiation, 2. Vascular proliferation, 3. Accumulation of inflammatory cells, particularly T lymphocytes and neutrophils within the dermal and epidermal compartments of the skin. Current evidence strongly indicates that psoriasis is primarily a T lymphocyte driven disease and that other changes observed are secondary to T-helper cell effector mechanisms.Important evidence includes; 1. Immunohistochemical studies showing early infiltration in T lymphocytes into evolving lesions, 2. Genetic studies showing linkage disequilibrium between psoriasis and a locus in the MHC on chromosome 6p.

Immunology of Psoriasis

3. Studies showing psoriasis responding to treatment with anti T-cell agents such as Cyclosporin A, and DAB389-IL2.While guttate and occasionally chronic plaque psoriasis can be precipitated by streptococcal infection, there is evidence that psoriasis is an antigen driven response. Furthermore, in some studies the pattern of the TCR expressed in psoriatic plaques is consistent with bacterial super antigens being responsible. Of further importance is the observation that streptococcal super antigens can induce expression of the skin homing receptor, CLA, on lymphocytes, thereby providing a mechanism for this effect.

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Welcome to Psoriasis Cure Bangalore, VEDAM AYURVEDA MULTI-SPECIALTIES. As you are well aware still I wish to remind you that AYURVEDA is the science of Life.

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